Identification of Flavonoids as Putative ROS-1 Kinase Inhibitors Using Pharmacophore Modeling for NSCLC Therapeutics

Identification of Flavonoids as Putative ROS-1 Kinase Inhibitors Using Pharmacophore Modeling for NSCLC Therapeutics

Non-small cell lung cancer (NSCLC) is a lethal non-immunogenic malignancy and proto-oncogene ROS-1 tyrosine kinase is one of its clinically relevant oncogenic markers. The ROS-1 inhibitor, crizotinib, demonstrated resistance due to the Gly2032Arg mutation. To curtail this resistance, researchers dev...

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Bibliographic Details
Main Authors: Shraddha Parate, Vikas Kumar, Jong Chan Hong, Keun Woo Lee
Format: Article
Language:English
Published: MDPI AG 2021-04-01
Series:Molecules
Subjects:
ROS-1 kinase
drug resistance
NSCLC
flavonoids
structure-based pharmacophore
virtual screening
Online Access:https://www.mdpi.com/1420-3049/26/8/2114

Internet

https://www.mdpi.com/1420-3049/26/8/2114

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