Discovery of breast cancer risk genes and establishment of a prediction model based on estrogen metabolism regulation

Discovery of breast cancer risk genes and establishment of a prediction model based on estrogen metabolism regulation

Abstract Background Multiple common variants identified by genome-wide association studies have shown limited evidence of the risk of breast cancer in Chinese individuals. In this study, we aimed to uncover the relationship between estrogen levels and the genetic polymorphism of estrogen metabolism-...

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Bibliographic Details
Main Authors: Feng Zhao, Zhixiang Hao, Yanan Zhong, Yinxue Xu, Meng Guo, Bei Zhang, Xiaoxing Yin, Ying Li, Xueyan Zhou
Format: Article
Language:English
Published: BMC 2021-02-01
Series:BMC Cancer
Subjects:
Breast cancer
Risk prediction
Estrogens
Estrogen-metabolizing enzyme
Gene polymorphism
Polygenic risk score
Online Access:https://doi.org/10.1186/s12885-021-07896-4

Internet

https://doi.org/10.1186/s12885-021-07896-4

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