Expeditive synthesis of trithiotriazine-cored glycoclusters and inhibition of Pseudomonas aeruginosa biofilm formation

Expeditive synthesis of trithiotriazine-cored glycoclusters and inhibition of Pseudomonas aeruginosa biofilm formation

Readily accessible, low-valency glycoclusters based on a triazine core bearing D-galactose and L-fucose epitopes are able to inhibit biofilm formation by Pseudomonas aeruginosa. These multivalent ligands are simple to synthesize, are highly soluble, and can be either homofunctional or heterofunction...

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Bibliographic Details
Main Authors: Meriem Smadhi, Sophie de Bentzmann, Anne Imberty, Marc Gingras, Raoudha Abderrahim, Peter G. Goekjian
Format: Article
Language:English
Published: Beilstein-Institut 2014-08-01
Series:Beilstein Journal of Organic Chemistry
Subjects:
antibiotic
biofilm
glycocluster
lectin
multivalency effect
multivalent glycosystems
Online Access:https://doi.org/10.3762/bjoc.10.206

Internet

https://doi.org/10.3762/bjoc.10.206

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