Resting state brain dynamics: Associations with childhood sexual abuse and major depressive disorder
Early life stress (ELS) and major depressive disorder (MDD) share neural network abnormalities. However, it is unclear how ELS and MDD may separately and/or jointly relate to brain networks, and whether neural differences exist between depressed individuals with vs without ELS. Moreover, prior work...
| Main Authors: | , , , , , , , , , , , |
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| Format: | Article |
| Language: | English |
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Elsevier
2022-01-01
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| Series: | NeuroImage: Clinical |
| Subjects: | |
| Online Access: | http://www.sciencedirect.com/science/article/pii/S2213158222002297 |
| _version_ | 1828254386296455168 |
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| author | Emily L. Belleau Thomas A.W. Bolton Roselinde H. Kaiser Rachel Clegg Emilia Cárdenas Franziska Goer Pia Pechtel Miranda Beltzer Gordana Vitaliano David P. Olson Martin H. Teicher Diego A. Pizzagalli |
| author_facet | Emily L. Belleau Thomas A.W. Bolton Roselinde H. Kaiser Rachel Clegg Emilia Cárdenas Franziska Goer Pia Pechtel Miranda Beltzer Gordana Vitaliano David P. Olson Martin H. Teicher Diego A. Pizzagalli |
| author_sort | Emily L. Belleau |
| collection | DOAJ |
| description | Early life stress (ELS) and major depressive disorder (MDD) share neural network abnormalities. However, it is unclear how ELS and MDD may separately and/or jointly relate to brain networks, and whether neural differences exist between depressed individuals with vs without ELS. Moreover, prior work evaluated static versus dynamic network properties, a critical gap considering brain networks show changes in coordinated activity over time. Seventy-one unmedicated females with and without childhood sexual abuse (CSA) histories and/or MDD completed a resting state scan and a stress task in which cortisol and affective ratings were collected. Recurring functional network co-activation patterns (CAPs) were examined and time in CAP (number of times each CAP is expressed) and transition frequencies (transitioning between different CAPs) were computed. The effects of MDD and CSA on CAP metrics were examined and CAP metrics were correlated with depression and stress-related variables. Results showed that MDD, but not CSA, related to CAP metrics. Specifically, individuals with MDD (N = 35) relative to HCs (N = 36), spent more time in a posterior default mode (DMN)-frontoparietal network (FPN) CAP and transitioned more frequently between posterior DMN-FPN and prototypical DMN CAPs. Across groups, more time spent in a posterior DMN-FPN CAP and greater DMN-FPN and prototypical DMN CAP transition frequencies were linked to higher rumination. Imbalances between the DMN and the FPN appear central to MDD and might contribute to MDD-related cognitive dysfunction, including rumination. Unexpectedly, CSA did not modulate such dysfunctions, a finding that needs to be replicated by future studies with larger sample sizes. |
| first_indexed | 2024-04-13T01:57:19Z |
| format | Article |
| id | doaj.art-88b62f77e59b42219cbfa50ce27a7904 |
| institution | Directory Open Access Journal |
| issn | 2213-1582 |
| language | English |
| last_indexed | 2024-04-13T01:57:19Z |
| publishDate | 2022-01-01 |
| publisher | Elsevier |
| record_format | Article |
| series | NeuroImage: Clinical |
| spelling | doaj.art-88b62f77e59b42219cbfa50ce27a79042022-12-22T03:07:43ZengElsevierNeuroImage: Clinical2213-15822022-01-0136103164Resting state brain dynamics: Associations with childhood sexual abuse and major depressive disorderEmily L. Belleau0Thomas A.W. Bolton1Roselinde H. Kaiser2Rachel Clegg3Emilia Cárdenas4Franziska Goer5Pia Pechtel6Miranda Beltzer7Gordana Vitaliano8David P. Olson9Martin H. Teicher10Diego A. Pizzagalli11Center for Depression, Anxiety and Stress Research, McLean Hospital, Belmont, MA, USA; Department of Psychiatry, Harvard Medical School, Boston, MA, USA; Corresponding author at: 115 Mill Street, Belmont, MA 02478, USA.Department of Clinical Neurosciences, Neurosurgery Service and Gamma Knife Center, Centre Hospitalier Universitaire Vaudois (CHUV), Lausanne, SwitzerlandDepartment of Psychology and Neuroscience, University of Colorado Boulder, Boulder, USACenter for Depression, Anxiety and Stress Research, McLean Hospital, Belmont, MA, USACenter for Depression, Anxiety and Stress Research, McLean Hospital, Belmont, MA, USACenter for Depression, Anxiety and Stress Research, McLean Hospital, Belmont, MA, USACenter for Depression, Anxiety and Stress Research, McLean Hospital, Belmont, MA, USACenter for Depression, Anxiety and Stress Research, McLean Hospital, Belmont, MA, USADepartment of Psychiatry, Harvard Medical School, Boston, MA, USA; McLean Imaging Center, McLean Hospital, Belmont, MA, USADepartment of Psychiatry, Harvard Medical School, Boston, MA, USA; McLean Imaging Center, McLean Hospital, Belmont, MA, USADepartment of Psychiatry, Harvard Medical School, Boston, MA, USACenter for Depression, Anxiety and Stress Research, McLean Hospital, Belmont, MA, USA; Department of Psychiatry, Harvard Medical School, Boston, MA, USA; McLean Imaging Center, McLean Hospital, Belmont, MA, USAEarly life stress (ELS) and major depressive disorder (MDD) share neural network abnormalities. However, it is unclear how ELS and MDD may separately and/or jointly relate to brain networks, and whether neural differences exist between depressed individuals with vs without ELS. Moreover, prior work evaluated static versus dynamic network properties, a critical gap considering brain networks show changes in coordinated activity over time. Seventy-one unmedicated females with and without childhood sexual abuse (CSA) histories and/or MDD completed a resting state scan and a stress task in which cortisol and affective ratings were collected. Recurring functional network co-activation patterns (CAPs) were examined and time in CAP (number of times each CAP is expressed) and transition frequencies (transitioning between different CAPs) were computed. The effects of MDD and CSA on CAP metrics were examined and CAP metrics were correlated with depression and stress-related variables. Results showed that MDD, but not CSA, related to CAP metrics. Specifically, individuals with MDD (N = 35) relative to HCs (N = 36), spent more time in a posterior default mode (DMN)-frontoparietal network (FPN) CAP and transitioned more frequently between posterior DMN-FPN and prototypical DMN CAPs. Across groups, more time spent in a posterior DMN-FPN CAP and greater DMN-FPN and prototypical DMN CAP transition frequencies were linked to higher rumination. Imbalances between the DMN and the FPN appear central to MDD and might contribute to MDD-related cognitive dysfunction, including rumination. Unexpectedly, CSA did not modulate such dysfunctions, a finding that needs to be replicated by future studies with larger sample sizes.http://www.sciencedirect.com/science/article/pii/S2213158222002297DepressionEarly life stressCo-activation pattern analysisResting state fMRIRuminationBrain network dynamics |
| spellingShingle | Emily L. Belleau Thomas A.W. Bolton Roselinde H. Kaiser Rachel Clegg Emilia Cárdenas Franziska Goer Pia Pechtel Miranda Beltzer Gordana Vitaliano David P. Olson Martin H. Teicher Diego A. Pizzagalli Resting state brain dynamics: Associations with childhood sexual abuse and major depressive disorder NeuroImage: Clinical Depression Early life stress Co-activation pattern analysis Resting state fMRI Rumination Brain network dynamics |
| title | Resting state brain dynamics: Associations with childhood sexual abuse and major depressive disorder |
| title_full | Resting state brain dynamics: Associations with childhood sexual abuse and major depressive disorder |
| title_fullStr | Resting state brain dynamics: Associations with childhood sexual abuse and major depressive disorder |
| title_full_unstemmed | Resting state brain dynamics: Associations with childhood sexual abuse and major depressive disorder |
| title_short | Resting state brain dynamics: Associations with childhood sexual abuse and major depressive disorder |
| title_sort | resting state brain dynamics associations with childhood sexual abuse and major depressive disorder |
| topic | Depression Early life stress Co-activation pattern analysis Resting state fMRI Rumination Brain network dynamics |
| url | http://www.sciencedirect.com/science/article/pii/S2213158222002297 |
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