The Cytotoxic Effects of Cannabidiol and Cannabigerol on Glioblastoma Stem Cells May Mostly Involve GPR55 and TRPV1 Signalling

The Cytotoxic Effects of Cannabidiol and Cannabigerol on Glioblastoma Stem Cells May Mostly Involve GPR55 and TRPV1 Signalling

Glioblastoma (GBM) is one of the most aggressive cancers, comprising 60–70% of all gliomas. The large G-protein-coupled receptor family includes cannabinoid receptors CB1, CB2, GPR55, and non-specific ion receptor protein transporters TRPs. First, we found up-regulated <i>CNR1, GPR55</i>...

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Bibliographic Details
Main Authors: Tamara T. Lah, Bernarda Majc, Metka Novak, Ajda Sušnik, Barbara Breznik, Andrej Porčnik, Roman Bošnjak, Aleksander Sadikov, Marta Malavolta, Selma Halilčević, Jernej Mlakar, Roby Zomer
Format: Article
Language:English
Published: MDPI AG 2022-11-01
Series:Cancers
Subjects:
glioblastoma
glioma
cannabigerol
cannabidiol
cannabinoid receptors
stem cells
Online Access:https://www.mdpi.com/2072-6694/14/23/5918

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https://www.mdpi.com/2072-6694/14/23/5918

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