Production of large, defined genome modifications in rats by targeting rat embryonic stem cells

Production of large, defined genome modifications in rats by targeting rat embryonic stem cells

Summary: Rats were more frequently used than mice to model human disease before mouse embryonic stem cells (mESCs) revolutionized genetic engineering in mice. Rat ESCs (rESCs) were first reported over 10 years ago, yet they are not as frequently used as mESCs. CRISPR-based gene editing in zygotes is...

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Bibliographic Details
Main Authors: Jeffrey Lee, Jingjing Wang, Roxanne Ally, Sean Trzaska, Joseph Hickey, Alejo Mujica, Lawrence Miloscio, Jason Mastaitis, Brian Morse, Janell Smith, Amanda Atanasio, Eric Chiao, Henry Chen, Adrianna Latuszek, Ying Hu, David Valenzuela, Carmelo Romano, Brian Zambrowicz, Wojtek Auerbach
Format: Article
Language:English
Published: Elsevier 2023-01-01
Series:Stem Cell Reports
Subjects:
rat
embryonic stem cells
genetic modification
germline transmission
disease models
Online Access:http://www.sciencedirect.com/science/article/pii/S2213671122005458

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http://www.sciencedirect.com/science/article/pii/S2213671122005458

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