Loss of Extrasynaptic Inhibitory Glycine Receptors in the Hippocampus of an AD Mouse Model Is Restored by Treatment with Artesunate

Loss of Extrasynaptic Inhibitory Glycine Receptors in the Hippocampus of an AD Mouse Model Is Restored by Treatment with Artesunate

Alzheimer’s disease (AD) is characterized by synaptic failure and neuronal loss. Recently, we demonstrated that artemisinins restored the levels of key proteins of inhibitory GABAergic synapses in the hippocampus of APP/PS1 mice, a model of cerebral amyloidosis. In the present study, we analyzed the...

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Bibliographic Details
Main Authors: Jochen Kuhse, Femke Groeneweg, Stefan Kins, Karin Gorgas, Ralph Nawrotzki, Joachim Kirsch, Eva Kiss
Format: Article
Language:English
Published: MDPI AG 2023-02-01
Series:International Journal of Molecular Sciences
Subjects:
artemisinins
Alzheimer’s disease
glycine receptor
APP/PS1
Online Access:https://www.mdpi.com/1422-0067/24/5/4623

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https://www.mdpi.com/1422-0067/24/5/4623

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