Blinatumomab-induced T cell activation at single cell transcriptome resolution

Blinatumomab-induced T cell activation at single cell transcriptome resolution

Abstract Background Bi-specific T-cell engager (BiTE) antibody is a class of bispecific antibodies designed for cancer immunotherapy. Blinatumomab is the first approved BiTE to treat acute B cell lymphoblastic leukemia (B-ALL). It brings killer T and target B cells into close proximity, activating p...

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Bibliographic Details
Main Authors: Yi Huo, Zhen Sheng, Daniel R. Lu, Daniel C. Ellwanger, Chi-Ming Li, Oliver Homann, Songli Wang, Hong Yin, Ruibao Ren
Format: Article
Language:English
Published: BMC 2021-03-01
Series:BMC Genomics
Subjects:
Bi-specific T-cell engager antibody
Acute B cell lymphoblastic leukemia
Blinatumomab
T cell activation
Single-cell RNA-Seq
TNFRSF4
Online Access:https://doi.org/10.1186/s12864-021-07435-2

Internet

https://doi.org/10.1186/s12864-021-07435-2

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