PKC-mediated phosphorylation and activation of the MEK/ERK pathway as a mechanism of acquired trastuzumab resistance in HER2-positive breast cancer

PKC-mediated phosphorylation and activation of the MEK/ERK pathway as a mechanism of acquired trastuzumab resistance in HER2-positive breast cancer

Protein expression, activation and stability are regulated through inter-connected signal transduction pathways resulting in specific cellular states. This study sought to differentiate between the complex mechanisms of intrinsic and acquired trastuzumab resistance, by quantifying changes in express...

Full description

Bibliographic Details
Main Authors: Jeanesse Scerri, Christian Scerri, Felix Schäfer-Ruoff, Simon Fink, Markus Templin, Godfrey Grech
Format: Article
Language:English
Published: Frontiers Media S.A. 2022-10-01
Series:Frontiers in Endocrinology
Subjects:
acquired resistance
breast cancer
phospho-profile
PKC/MEK/ERK
signalosome
HER2 positive
Online Access:https://www.frontiersin.org/articles/10.3389/fendo.2022.1010092/full

Internet

https://www.frontiersin.org/articles/10.3389/fendo.2022.1010092/full

Similar Items