PKC-mediated phosphorylation and activation of the MEK/ERK pathway as a mechanism of acquired trastuzumab resistance in HER2-positive breast cancer

PKC-mediated phosphorylation and activation of the MEK/ERK pathway as a mechanism of acquired trastuzumab resistance in HER2-positive breast cancer

Protein expression, activation and stability are regulated through inter-connected signal transduction pathways resulting in specific cellular states. This study sought to differentiate between the complex mechanisms of intrinsic and acquired trastuzumab resistance, by quantifying changes in express...

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Bibliographic Details
Main Authors: Jeanesse Scerri, Christian Scerri, Felix Schäfer-Ruoff, Simon Fink, Markus Templin, Godfrey Grech
Format: Article
Language:English
Published: Frontiers Media S.A. 2022-10-01
Series:Frontiers in Endocrinology
Subjects:
acquired resistance
breast cancer
phospho-profile
PKC/MEK/ERK
signalosome
HER2 positive
Online Access:https://www.frontiersin.org/articles/10.3389/fendo.2022.1010092/full

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