Patient-derived lymphoblastoid cell lines harboring mitochondrial DNA mutations as tool for small molecule drug discovery

Patient-derived lymphoblastoid cell lines harboring mitochondrial DNA mutations as tool for small molecule drug discovery

Abstract Objective Mitochondrial diseases are a group of devastating disorders for which there is no transformative cure. The majority of therapies for mitochondrial disease—approved, previously tested, or currently in development—are small molecules. The implementation of better cell-based models o...

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Bibliographic Details
Main Authors: Randall Marcelo Chin, Tadas Panavas, Jeffrey M. Brown, Krista K. Johnson
Format: Article
Language:English
Published: BMC 2018-03-01
Series:BMC Research Notes
Subjects:
Mitochondria
Idebenone
Respiration
Mitochondrial disease
ND1
ND4
Online Access:http://link.springer.com/article/10.1186/s13104-018-3297-6

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http://link.springer.com/article/10.1186/s13104-018-3297-6

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