Immunomodulatory matrix-bound nanovesicles mitigate acute and chronic pristane-induced rheumatoid arthritis

Abstract Rheumatoid arthritis (RA) is an autoimmune disease characterized by chronic inflammation and destruction of synovial joints affecting ~7.5 million people worldwide. Disease pathology is driven by an imbalance in the ratio of pro-inflammatory vs. anti-inflammatory immune cells, especially ma...

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Bibliographic Details
Main Authors: Raphael J. Crum, Kelsey Hall, Catalina Pineda Molina, George S. Hussey, Emma Graham, Hongshuai Li, Stephen F. Badylak
Format: Article
Language:English
Published: Nature Portfolio 2022-02-01
Series:npj Regenerative Medicine
Online Access:https://doi.org/10.1038/s41536-022-00208-9