Ketamine metabolite alleviates morphine withdrawal-induced anxiety via modulating nucleus accumbens parvalbumin neurons in male mice

Ketamine metabolite alleviates morphine withdrawal-induced anxiety via modulating nucleus accumbens parvalbumin neurons in male mice

Opioid withdrawal generates extremely unpleasant physical symptoms and negative affective states. A rapid relief of opioid withdrawal-induced anxiety has obvious clinical relevance but has been rarely reported. We have shown that injection of ketamine metabolite (2R,6R)-hydroxynorketamine (HNK) lead...

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Bibliographic Details
Main Authors: Yuanyuan Chen, Peng Yan, Shuguang Wei, Yongsheng Zhu, Jianghua Lai, Qiang Zhou
Format: Article
Language:English
Published: Elsevier 2023-10-01
Series:Neurobiology of Disease
Subjects:
Morphine withdrawal
Anxiety
Nucleus accumbens
Parvalbumin
(2R,6R)-hydroxynorketamine
Online Access:http://www.sciencedirect.com/science/article/pii/S0969996123002942

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http://www.sciencedirect.com/science/article/pii/S0969996123002942

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