Intratumoral injection of melatonin enhances tumor regression in cell line-derived and patient-derived xenografts of head and neck cancer by increasing mitochondrial oxidative stress

Intratumoral injection of melatonin enhances tumor regression in cell line-derived and patient-derived xenografts of head and neck cancer by increasing mitochondrial oxidative stress

Head and neck squamous cell carcinoma present a high mortality rate. Melatonin has been shown to have oncostatic effects in different types of cancers. However, inconsistent results have been reported for in vivo applications. Consequently, an alternative administration route is needed to improve bi...

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Bibliographic Details
Main Authors: Laura Martinez-Ruiz, Javier Florido, César Rodriguez-Santana, Alba López-Rodríguez, Ana Guerra-Librero, Beatriz I. Fernández-Gil, Patricia García-Tárraga, José Manuel Garcia-Verdugo, Felix Oppel, Holger Sudhoff, David Sánchez-Porras, Amadeo Ten-Steve, José Fernández-Martínez, Pilar González-García, Iryna Rusanova, Darío Acuña-Castroviejo, Víctor Carriel, Germaine Escames
Format: Article
Language:English
Published: Elsevier 2023-11-01
Series:Biomedicine & Pharmacotherapy
Subjects:
Melatonin
Intratumoral injection
Patient-derived xenograft
Head and neck cancer
Mitochondria
Reactive oxygen species
Online Access:http://www.sciencedirect.com/science/article/pii/S0753332223013161

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http://www.sciencedirect.com/science/article/pii/S0753332223013161

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