STAT3 Activity Promotes Programmed-Death Ligand 1 Expression and Suppresses Immune Responses in Breast Cancer

STAT3 Activity Promotes Programmed-Death Ligand 1 Expression and Suppresses Immune Responses in Breast Cancer

Signal transducer and activator of transcription 3 (STAT3) is an oncogene and multifaceted transcription factor involved in multiple cellular functions. Its role in modifying anti-tumor immunity has been recently recognized. In this study, the biologic effects of STAT3 on immune checkpoint expressio...

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Bibliographic Details
Main Authors: Ioannis Zerdes, Majken Wallerius, Emmanouil G. Sifakis, Tatjana Wallmann, Stina Betts, Margarita Bartish, Nikolaos Tsesmetzis, Nicholas P. Tobin, Christos Coucoravas, Jonas Bergh, George Z. Rassidakis, Charlotte Rolny, Theodoros Foukakis
Format: Article
Language:English
Published: MDPI AG 2019-10-01
Series:Cancers
Subjects:
breast cancer
pd-l1
stat3
m2 macrophages
nk cells
stat3 inhibitor xiii
Online Access:https://www.mdpi.com/2072-6694/11/10/1479

Internet

https://www.mdpi.com/2072-6694/11/10/1479

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