Fighting the Fire: Mechanisms of Inflammatory Gene Regulation by the Glucocorticoid Receptor

Fighting the Fire: Mechanisms of Inflammatory Gene Regulation by the Glucocorticoid Receptor

For many decades, glucocorticoids have been widely used as the gold standard treatment for inflammatory conditions. Unfortunately, their clinical use is limited by severe adverse effects such as insulin resistance, cardiometabolic diseases, muscle and skin atrophies, osteoporosis, and depression. Gl...

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Bibliographic Details
Main Authors: Laura Escoter-Torres, Giorgio Caratti, Aikaterini Mechtidou, Jan Tuckermann, Nina Henriette Uhlenhaut, Sabine Vettorazzi
Format: Article
Language:English
Published: Frontiers Media S.A. 2019-08-01
Series:Frontiers in Immunology
Subjects:
glucocorticoid receptor
inflammation
macrophages
mouse models
gene regulation
Online Access:https://www.frontiersin.org/article/10.3389/fimmu.2019.01859/full

Internet

https://www.frontiersin.org/article/10.3389/fimmu.2019.01859/full

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