CFTR-mediated anion secretion in parathyroid hormone-treated Caco-2 cells is associated with PKA and PI3K phosphorylation but not intracellular pH changes or Na+/K+-ATPase abundance

CFTR-mediated anion secretion in parathyroid hormone-treated Caco-2 cells is associated with PKA and PI3K phosphorylation but not intracellular pH changes or Na+/K+-ATPase abundance

Parathyroid hormone (PTH) has previously been shown to enhance the transepithelial secretion of Cl− and HCO3− across the intestinal epithelia including Caco-2 monolayer, but the underlying cellular mechanisms are not completely understood. Herein, we identified the major signaling pathways that poss...

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Bibliographic Details
Main Authors: Rattana Chaimana, Jarinthorn Teerapornpuntakit, Walailak Jantarajit, Kornkamon Lertsuwan, Saowalak Krungchanuchat, Nattapon Panupinthu, Nateetip Krishnamra, Narattaphol Charoenphandhu
Format: Article
Language:English
Published: Elsevier 2021-09-01
Series:Biochemistry and Biophysics Reports
Subjects:
Anion secretion
Cystic fibrosis transmembrane conductance regulator (CFTR)
Parathyroid hormone (PTH)
Parathyroid hormone 1 receptor (PTH1R)
Phosphoinositide 3-kinase (PI3K)
Protein kinase A (PKA)
Online Access:http://www.sciencedirect.com/science/article/pii/S2405580821001485

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http://www.sciencedirect.com/science/article/pii/S2405580821001485

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