The Cross Marks the Spot: The Emerging Role of JmjC Domain-Containing Proteins in Myeloid Malignancies

The Cross Marks the Spot: The Emerging Role of JmjC Domain-Containing Proteins in Myeloid Malignancies

Histone methylation tightly regulates chromatin accessibility, transcription, proliferation, and cell differentiation, and its perturbation contributes to oncogenic reprogramming of cells. In particular, many myeloid malignancies show evidence of epigenetic dysregulation. Jumonji C (JmjC) domain-con...

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Bibliographic Details
Main Authors: Hans Felix Staehle, Heike Luise Pahl, Jonas Samuel Jutzi
Format: Article
Language:English
Published: MDPI AG 2021-12-01
Series:Biomolecules
Subjects:
KDM
Jumonji C (JmjC) domain
histone demethylation
leukemia
myelodysplastic syndrome
myeloproliferative neoplasm
Online Access:https://www.mdpi.com/2218-273X/11/12/1911

Internet

https://www.mdpi.com/2218-273X/11/12/1911

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