Stapled peptide inhibitors of RAB25 target context-specific phenotypes in cancer

Stapled peptide inhibitors of RAB25 target context-specific phenotypes in cancer

The Ras-family small GTPase RAB25 can exert both pro- and anti-oncogenic functions. Here, the authors develop all-hydrocarbon stabilized peptides targeting RAB25 and influencing the context-specificity phenotypes in cancer cell lines.

Bibliographic Details
Main Authors: Shreya Mitra, Jeffrey E. Montgomery, Matthew J. Kolar, Gang Li, Kang J. Jeong, Bo Peng, Gregory L. Verdine, Gordon B. Mills, Raymond E. Moellering
Format: Article
Language:English
Published: Nature Portfolio 2017-09-01
Series:Nature Communications
Online Access:https://doi.org/10.1038/s41467-017-00888-8

Internet

https://doi.org/10.1038/s41467-017-00888-8

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