Knockdown of LMNA inhibits Akt/β-catenin-mediated cell invasion and migration in clear cell renal cell carcinoma cells

Knockdown of LMNA inhibits Akt/β-catenin-mediated cell invasion and migration in clear cell renal cell carcinoma cells

ABSTRACTThe LMNA gene encoding lamin A/C is amplified in some clear cell renal cell carcinoma (ccRCC) samples. Our data showed that depletion of the tumor suppressor PBRM1 can upregulate lamin A/C levels, and lamin A/C could interact with PBRM1. However, the role of lamin A/C in ccRCC is not yet ful...

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Bibliographic Details
Main Authors: Hui Xin, Yu Tang, Yan-Hong Jin, Hu-Li Li, Yu Tian, Cong Yu, Ze-Ju Zhao, Ming-Song Wu, You-Fu Pan
Format: Article
Language:English
Published: Taylor & Francis Group 2023-12-01
Series:Cell Adhesion & Migration
Subjects:
ccRCC
LMNA
PBRM1
PI3K/AKT
β-catenin
Online Access:https://www.tandfonline.com/doi/10.1080/19336918.2023.2260644

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https://www.tandfonline.com/doi/10.1080/19336918.2023.2260644

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