The apparent loss of PRC2 chromatin occupancy as an artifact of RNA depletion

Summary: RNA has been implicated in the recruitment of chromatin modifiers, and previous studies have provided evidence in favor and against this idea. RNase treatment of chromatin is commonly used to study RNA-mediated regulation of chromatin modifiers, but the limitations of this approach remain u...

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Bibliographic Details
Main Authors: Evan Healy, Qi Zhang, Emma H. Gail, Samuel C. Agius, Guizhi Sun, Michael Bullen, Varun Pandey, Partha Pratim Das, Jose M. Polo, Chen Davidovich
Format: Article
Language:English
Published: Elsevier 2024-03-01
Series:Cell Reports
Subjects:
Online Access:http://www.sciencedirect.com/science/article/pii/S2211124724001864