Study of PARP inhibitors for breast cancer based on enhanced multiple kernel function SVR with PSO

Study of PARP inhibitors for breast cancer based on enhanced multiple kernel function SVR with PSO

PARP1 is one of six enzymes required for the highly error-prone DNA repair pathway microhomology-mediated end joining (MMEJ) and needs to be inhibited when over-expressed. In order to study the PARP1 inhibitory effect of fused tetracyclic or pentacyclic dihydrodiazepinoindolone derivatives (FTPDDs)...

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Bibliographic Details
Main Authors: Haohan Xue, Ruixuan Zhang, Xudong Yan, Ruihan Wang, Peijian Zhang
Format: Article
Language:English
Published: Frontiers Media S.A. 2024-02-01
Series:Frontiers in Pharmacology
Subjects:
breast cancer
PARP inhibitor
quantitative structure-activity relationship (QSAR)
support vector regression (SVR)
multiple kernel function
particle swarm optimization (PSO)
Online Access:https://www.frontiersin.org/articles/10.3389/fphar.2024.1257253/full

Internet

https://www.frontiersin.org/articles/10.3389/fphar.2024.1257253/full

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