Identifying Balanced Chromosomal Translocations in Human Embryos by Oxford Nanopore Sequencing and Breakpoints Region Analysis

Identifying Balanced Chromosomal Translocations in Human Embryos by Oxford Nanopore Sequencing and Breakpoints Region Analysis

Background: Balanced chromosomal aberrations, especially balanced translocations, can cause infertility, recurrent miscarriage or having chromosomally defective offspring. Preimplantation genetic testing for structural rearrangement (PGT-SR) has been widely implemented to improve the clinical outcom...

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Bibliographic Details
Main Authors: Zhenle Pei, Ke Deng, Caixai Lei, Danfeng Du, Guoliang Yu, Xiaoxi Sun, Congjian Xu, Shuo Zhang
Format: Article
Language:English
Published: Frontiers Media S.A. 2022-01-01
Series:Frontiers in Genetics
Subjects:
balanced translocation
preimplantation genetic testing
long-read sequencing
breakpoint PCR
haplotype linkage analysis
Online Access:https://www.frontiersin.org/articles/10.3389/fgene.2021.810900/full

Internet

https://www.frontiersin.org/articles/10.3389/fgene.2021.810900/full

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