Optimal control analysis of combined chemotherapy-immunotherapy treatment regimens in a PKPD cancer evolution model
The author constructs a mathematical model capturing tumor-immune dynamics, incorporating the evolution of drug resistance, pharmacokinetics and pharmacodynamics of administered drugs, and immunotherapy possibilities. Numerical simulations are performed to analyze the model under a variety of treatm...
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| Format: | Article |
| Language: | English |
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Bulgarian Academy of Sciences, Institute of Mathematics and Informatics
2020-03-01
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| Series: | Biomath |
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| Online Access: | http://www.biomathforum.org/biomath/index.php/biomath/article/view/1318 |