Evaluation of recombinant human interferon beta 1b by liquid chromatography methods and bioassay

Evaluation of recombinant human interferon beta 1b by liquid chromatography methods and bioassay

Recombinant human interferon beta 1b (rhIFNβ-1b) is clinically used to treat multiple sclerosis. A reversed-phase liquid chromatography (RP-LC) method was carried out on a Jupiter C4 column (250 mm × 4.6 mm i.d.). The mobile phase A consisted of 0.1% trifluoroacetic acid (TFA) in water, and the mobi...

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Bibliographic Details
Main Authors: Francielle Santos da Silva, Maurício Elesbão Walter, Bruna Xavier, Rafaela Ferreira Perobelli, Guilherme Zanini Calegari, Douglas Franco Cardoso, Valquiria Guedes Perlin, Sérgio Luiz Dalmora
Format: Article
Language:English
Published: Universidade de São Paulo 2019-10-01
Series:Brazilian Journal of Pharmaceutical Sciences
Subjects:
Recombinant human Interferon beta 1b
Biotechnology-derived medicine
Bioassay
Reversed-phase liquid chromatography
Size-exclusion liquid chromatography
Online Access:http://www.scielo.br/scielo.php?script=sci_arttext&pid=S1984-82502019000100571&tlng=en

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http://www.scielo.br/scielo.php?script=sci_arttext&pid=S1984-82502019000100571&tlng=en

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