Sodium‐Glucose Cotransporter 2 Inhibitor Canagliflozin Antagonizes Salt‐Sensitive Hypertension Through Modifying Transient Receptor Potential Channels 3 Mediated Vascular Calcium Handling

Sodium‐Glucose Cotransporter 2 Inhibitor Canagliflozin Antagonizes Salt‐Sensitive Hypertension Through Modifying Transient Receptor Potential Channels 3 Mediated Vascular Calcium Handling

Background Salt‐sensitive hypertension is highly prevalent and associated with cardiorenal damage. Large clinical trials have demonstrated that SGLT2 (sodium‐glucose cotransporter 2) inhibitors exert hypotensive effect and cardiorenal protective benefits in patients with hypertension with and withou...

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Bibliographic Details
Main Authors: Yu Zhao, Li Li, Zongshi Lu, Yingru Hu, Hexuan Zhang, Fang Sun, Qiang Li, Chengkang He, Wentao Shu, Lijuan Wang, Tingbing Cao, Zhidan Luo, Zhencheng Yan, Daoyan Liu, Peng Gao, Zhiming Zhu
Format: Article
Language:English
Published: Wiley 2022-08-01
Series:Journal of the American Heart Association: Cardiovascular and Cerebrovascular Disease
Subjects:
NCX1
salt‐sensitive hypertension
SGLT2 inhibitor
TRPC3
vasocontraction
Online Access:https://www.ahajournals.org/doi/10.1161/JAHA.121.025328

Internet

https://www.ahajournals.org/doi/10.1161/JAHA.121.025328

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