Intermittent Hypoxia Triggers Early Cardiac Remodeling and Contractile Dysfunction in the Time‐Course of Ischemic Cardiomyopathy in Rats

Intermittent Hypoxia Triggers Early Cardiac Remodeling and Contractile Dysfunction in the Time‐Course of Ischemic Cardiomyopathy in Rats

BACKGROUND Sleep‐disordered breathing is associated with a poor prognosis (mortality) in patients with ischemic cardiomyopathy. The understanding of mechanisms linking intermittent hypoxia (IH), the key feature of sleep‐disordered breathing, to ischemic cardiomyopathy progression is crucial for iden...

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Bibliographic Details
Main Authors: Guillaume Bourdier, Maximin Détrait, Sophie Bouyon, Emeline Lemarié, Sandrine Brasseur, Stéphane Doutreleau, Jean‐Louis Pépin, Diane Godin‐Ribuot, Elise Belaidi, Claire Arnaud
Format: Article
Language:English
Published: Wiley 2020-08-01
Series:Journal of the American Heart Association: Cardiovascular and Cerebrovascular Disease
Subjects:
ER stress
hypoxia inducible factor‐1
intermittent hypoxia
ischemic cardiomyopathy
sleep‐disordered breathing
sympathetic activation
Online Access:https://www.ahajournals.org/doi/10.1161/JAHA.120.016369

Internet

https://www.ahajournals.org/doi/10.1161/JAHA.120.016369

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