Pleiotropic effect of the ABCG2 gene in gout: involvement in serum urate levels and progression from hyperuricemia to gout

Pleiotropic effect of the ABCG2 gene in gout: involvement in serum urate levels and progression from hyperuricemia to gout

Abstract Background The ABCG2 Q141K (rs2231142) and rs10011796 variants associate with hyperuricaemia (HU). The effect size of ABCG2 rs2231142 on urate is ~ 60% that of SLC2A9, yet the effect size on gout is greater. We tested the hypothesis that ABCG2 plays a role in the progression from HU to gout...

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Bibliographic Details
Main Authors: Rebekah Wrigley, Amanda J. Phipps-Green, Ruth K. Topless, Tanya J. Major, Murray Cadzow, Philip Riches, Anne-Kathrin Tausche, Matthijs Janssen, Leo A. B. Joosten, Tim L. Jansen, Alexander So, Jennie Harré Hindmarsh, Lisa K. Stamp, Nicola Dalbeth, Tony R. Merriman
Format: Article
Language:English
Published: BMC 2020-03-01
Series:Arthritis Research & Therapy
Subjects:
Gout
Urate
Hyperuricemia
ABCG2
Association
Polymorphism
Online Access:http://link.springer.com/article/10.1186/s13075-020-2136-z

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http://link.springer.com/article/10.1186/s13075-020-2136-z

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