Thymoquinone-Induced Tristetraprolin Inhibits Tumor Growth and Metastasis through Destabilization of MUC4 mRNA

Thymoquinone-Induced Tristetraprolin Inhibits Tumor Growth and Metastasis through Destabilization of MUC4 mRNA

Tristetraprolin (TTP), a well-characterized AU-rich element (ARE) binding protein, functions as a tumor suppressor gene. The purpose of this study was to investigate whether a bioactive substance derived from a natural medicinal plant affects the induction of TTP and to elucidate its mechanism. We e...

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Bibliographic Details
Main Authors: Se-Ra Lee, Jeong-Yeon Mun, Mi-So Jeong, Hyun-Hee Lee, Yun-Gil Roh, Won-Tae Kim, Min-Hye Kim, Jeonghoon Heo, Yung Hyun Choi, Su Jin Kim, Hee-Jae Cha, Mira Jun, Sun-Hee Leem
Format: Article
Language:English
Published: MDPI AG 2019-05-01
Series:International Journal of Molecular Sciences
Subjects:
TTP
TQ
MUC4
ARE
binding protein
bioactive substance
Online Access:https://www.mdpi.com/1422-0067/20/11/2614

Internet

https://www.mdpi.com/1422-0067/20/11/2614

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