Gliptins normalize posttraumatic hippocampal neurogenesis and restore cognitive function after controlled cortical impact on sensorimotor cortex

Gliptins normalize posttraumatic hippocampal neurogenesis and restore cognitive function after controlled cortical impact on sensorimotor cortex

Traumatic brain injury (TBI) often leads to long-term neurocognitive dysfunctions. Adult neurogenesis in the hippocampal dentate gyrus (DG) serves critical functions in cognition but can be disrupted by brain injury and insult in serval forms. In the present study, we explore the cellular and molecu...

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Bibliographic Details
Main Authors: Yu-Wen Hung, Guan-Ling Lu, Hwei-Hsien Chen, Hsiu-Hui Tung, Sheau-Ling Lee
Format: Article
Language:English
Published: Elsevier 2023-09-01
Series:Biomedicine & Pharmacotherapy
Subjects:
Sitagliptin
Vildagliptin
Traumatic brain injury
Hippocampal neurogenesis
Cognitive dysfunction
Drug reposition
Online Access:http://www.sciencedirect.com/science/article/pii/S0753332223010612

Internet

http://www.sciencedirect.com/science/article/pii/S0753332223010612

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