Lack of p53 function promotes radiation-induced mitotic catastrophe in mouse embryonic fibroblast cells

<p>Abstract</p> <p>Background</p> <p>We have demonstrated that in some human cancer cells both chronic mild heat and ionizing radiation exposures induce a transient block in S and G2 phases of the cell cycle. During this delay, cyclin B1 protein accumulates to supranorm...

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Bibliographic Details
Main Authors: Phillips Stacia L, Kosmacek Elizabeth A, Bertoldo Alessandro, Ianzini Fiorenza, Mackey Michael A
Format: Article
Language:English
Published: BMC 2006-04-01
Series:Cancer Cell International
Online Access:http://www.cancerci.com/content/6/1/11