Dopamine Transporter, PhosphoSerine129 α-Synuclein and α-Synuclein Levels in Aged LRRK2 G2019S Knock-In and Knock-Out Mice

Dopamine Transporter, PhosphoSerine129 α-Synuclein and α-Synuclein Levels in Aged LRRK2 G2019S Knock-In and Knock-Out Mice

The G2019S mutation in leucine rich-repeat kinase 2 (LRRK2) is a major cause of familial Parkinson’s disease. We previously reported that G2019S knock-in mice manifest dopamine transporter dysfunction and phosphoSerine129 α-synuclein (pSer129 α-syn) immunoreactivity elevation at 12 months of age, wh...

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Bibliographic Details
Main Authors: Chiara Domenicale, Daniela Mercatelli, Federica Albanese, Salvatore Novello, Fabrizio Vincenzi, Katia Varani, Michele Morari
Format: Article
Language:English
Published: MDPI AG 2022-04-01
Series:Biomedicines
Subjects:
DAT
G2019S knock-in
[<sup>3</sup>H]-DA uptake
D1994S kinase-dead
LRRK2
MLi-2
Online Access:https://www.mdpi.com/2227-9059/10/4/881

Internet

https://www.mdpi.com/2227-9059/10/4/881

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