Genetic loci and metabolic states associated with murine epigenetic aging

Genetic loci and metabolic states associated with murine epigenetic aging

Changes in DNA methylation (DNAm) are linked to aging. Here, we profile highly conserved CpGs in 339 predominantly female mice belonging to the BXD family for which we have deep longevity and genomic data. We use a ‘pan-mammalian’ microarray that provides a common platform for assaying the methylome...

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Bibliographic Details
Main Authors: Khyobeni Mozhui, Ake T Lu, Caesar Z Li, Amin Haghani, Jose Vladimir Sandoval-Sierra, Yibo Wu, Robert W Williams, Steve Horvath
Format: Article
Language:English
Published: eLife Sciences Publications Ltd 2022-04-01
Series:eLife
Subjects:
epigenetic clock
lifespan
entropy
DNA methylation
metabolism
diet
Online Access:https://elifesciences.org/articles/75244

Internet

https://elifesciences.org/articles/75244

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