Therapeutic glucocorticoids prevent bone loss but drive muscle wasting when administered in chronic polyarthritis

Therapeutic glucocorticoids prevent bone loss but drive muscle wasting when administered in chronic polyarthritis

Abstract Background Patients with rheumatoid arthritis (RA) experience extra-articular manifestations including osteoporosis and muscle wasting, which closely associate with severity of disease. Whilst therapeutic glucocorticoids (GCs) reduce inflammation in RA, their actions on muscle and bone meta...

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Bibliographic Details
Main Authors: C. G. Fenton, J. M. Webster, C. S. Martin, S. Fareed, C. Wehmeyer, H. Mackie, R. Jones, A. P. Seabright, J. W. Lewis, Y. C. Lai, C. S. Goodyear, S. W Jones, M. S. Cooper, G. G. Lavery, R. Langen, K. Raza, R. S. Hardy
Format: Article
Language:English
Published: BMC 2019-08-01
Series:Arthritis Research & Therapy
Subjects:
Polyarthritis
Glucocorticoids
Muscle wasting
Osteoporosis
Online Access:http://link.springer.com/article/10.1186/s13075-019-1962-3

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http://link.springer.com/article/10.1186/s13075-019-1962-3

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