CD8+ T cells specific for conserved, cross-reactive Gag epitopes with strong ability to suppress HIV-1 replication

CD8+ T cells specific for conserved, cross-reactive Gag epitopes with strong ability to suppress HIV-1 replication

Abstract Background Development of AIDS vaccines for effective prevention of circulating HIV-1 is required, but no trial has demonstrated definitive effects on the prevention. Several recent T-cell vaccine trials showed no protection against HIV-1 acquisition although the vaccines induced HIV-1-spec...

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Bibliographic Details
Main Authors: Hayato Murakoshi, Chengcheng Zou, Nozomi Kuse, Tomohiro Akahoshi, Takayuki Chikata, Hiroyuki Gatanaga, Shinichi Oka, Tomáš Hanke, Masafumi Takiguchi
Format: Article
Language:English
Published: BMC 2018-07-01
Series:Retrovirology
Subjects:
HIV-1
Gag
CTL
Vaccine
Conserved epitope
Online Access:http://link.springer.com/article/10.1186/s12977-018-0429-y

Internet

http://link.springer.com/article/10.1186/s12977-018-0429-y

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