NLRC5 overexpression in ovarian tumors remodels the tumor microenvironment and increases T-cell reactivity toward autologous tumor-associated antigens

NLRC5 overexpression in ovarian tumors remodels the tumor microenvironment and increases T-cell reactivity toward autologous tumor-associated antigens

IntroductionEpithelial ovarian cancer (OC) stands as one of the deadliest gynecologic malignancies, urgently necessitating novel therapeutic strategies. Approximately 60% of ovarian tumors exhibit reduced expression of major histocompatibility complex class I (MHC I), intensifying immune evasion mec...

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Bibliographic Details
Main Authors: Galaxia M. Rodriguez, Edward Yakubovich, Humaira Murshed, Vincent Maranda, Kristianne J.C. Galpin, Alison Cudmore, Andrew M. R. Hanna, Elizabeth Macdonald, Shashankan Ramesh, Kenneth Garson, Barbara C. Vanderhyden
Format: Article
Language:English
Published: Frontiers Media S.A. 2024-01-01
Series:Frontiers in Immunology
Subjects:
ovarian cancer
tumor immunogenicity
MHC I
NLRC5
tumor microenvironment
infected cell vaccine
Online Access:https://www.frontiersin.org/articles/10.3389/fimmu.2023.1295208/full

Internet

https://www.frontiersin.org/articles/10.3389/fimmu.2023.1295208/full

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