Kaempferol attenuates doxorubicin-mediated nephropathy in rats by activating SIRT1 signaling

Kaempferol attenuates doxorubicin-mediated nephropathy in rats by activating SIRT1 signaling

This study examined if sirtuin-1 (SIRT1) signaling mediates the nephroprotective effect of kaempferol in doxorubicin (DOX)-treated rats. Rats were divided into control, kaempferol, DOX, kaempferol + DOX, and kaempferol + DOX + EX-527 (a SIRT1 inhibitor). Kaempferol preserved the kidney structure and...

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Bibliographic Details
Main Authors: Reham I. Alagal, Nora A. AlFaris, Ghedeir M. Alshammari, Jozaa Z. ALTamimi, Lujain A. AlMousa, Mohammed Abdo Yahya
Format: Article
Language:English
Published: Elsevier 2022-02-01
Series:Journal of Functional Foods
Subjects:
Kaempferol
Doxorubicin
SIRT1
Nrf2
NF-κB
Oxidative stress
Online Access:http://www.sciencedirect.com/science/article/pii/S1756464621005673

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http://www.sciencedirect.com/science/article/pii/S1756464621005673

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