In Vitro Evaluation of Self-Nano-Emulsifying Drug Delivery Systems (SNEDDS) Containing Room Temperature Ionic Liquids (RTILs) for the Oral Delivery of Amphotericin B

In Vitro Evaluation of Self-Nano-Emulsifying Drug Delivery Systems (SNEDDS) Containing Room Temperature Ionic Liquids (RTILs) for the Oral Delivery of Amphotericin B

Amphotericin B (AmpB), one of the most commonly used agents in the treatment of severe fungal infections and life-threatening parasitic diseases such as visceral Leishmaniasis, has a negligible oral bioavailability, primarily due to a low solubility and permeability. To develop an oral formulation,...

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Bibliographic Details
Main Authors: Eleni Kontogiannidou, Thomas Meikopoulos, Helen Gika, Emmanuel Panteris, Ioannis S. Vizirianakis, Anette Müllertz, Dimitrios G. Fatouros
Format: Article
Language:English
Published: MDPI AG 2020-07-01
Series:Pharmaceutics
Subjects:
self-emulsifying drug delivery systems
amphotericin B
room temperature ionic liquids
Caco-2 cells
cytotoxicity
Online Access:https://www.mdpi.com/1999-4923/12/8/699

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https://www.mdpi.com/1999-4923/12/8/699

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