Reduced excitatory neurotransmission in the hippocampus after inflammation and sevoflurane anaesthesia

Reduced excitatory neurotransmission in the hippocampus after inflammation and sevoflurane anaesthesia

Background: Inflammation and general anaesthesia likely contribute to perioperative neurocognitive disorders, possibly by causing a neuronal imbalance of excitation and inhibition. We showed previously that treatment with lipopolysaccharide (LPS) and sevoflurane causes a sustained increase in a toni...

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Bibliographic Details
Main Authors: Shahin Khodaei, Dian-Shi Wang, Beverley A. Orser
Format: Article
Language:English
Published: Elsevier 2023-06-01
Series:BJA Open
Subjects:
excitatory neurotransmission
lipopolysaccharide
mEPSC
perioperative neurocognitive disorders
sevoflurane
synaptic plasticity
Online Access:http://www.sciencedirect.com/science/article/pii/S2772609623000229

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http://www.sciencedirect.com/science/article/pii/S2772609623000229

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