Beta-catenin/HuR post-transcriptional machinery governs cancer stem cell features in response to hypoxia.

Beta-catenin/HuR post-transcriptional machinery governs cancer stem cell features in response to hypoxia.

Hypoxia has been long-time acknowledged as major cancer-promoting microenvironment. In such an energy-restrictive condition, post-transcriptional mechanisms gain importance over the energy-expensive gene transcription machinery. Here we show that the onset of hypoxia-induced cancer stem cell feature...

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Bibliographic Details
Main Authors: Gabriele D'Uva, Sara Bertoni, Mattia Lauriola, Sabrina De Carolis, Annalisa Pacilli, Laura D'Anello, Donatella Santini, Mario Taffurelli, Claudio Ceccarelli, Yosef Yarden, Lorenzo Montanaro, Massimiliano Bonafé, Gianluca Storci
Format: Article
Language:English
Published: Public Library of Science (PLoS) 2013-01-01
Series:PLoS ONE
Online Access:http://europepmc.org/articles/PMC3829939?pdf=render

Internet

http://europepmc.org/articles/PMC3829939?pdf=render

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