Characterization of the DNAM-1, TIGIT and TACTILE Axis on Circulating NK, NKT-Like and T Cell Subsets in Patients with Acute Myeloid Leukemia

Characterization of the DNAM-1, TIGIT and TACTILE Axis on Circulating NK, NKT-Like and T Cell Subsets in Patients with Acute Myeloid Leukemia

<i>Background</i>: Acute myeloid leukemia (AML) remains a major clinical challenge due to poor overall survival, which is even more dramatic in elderly patients. TIGIT, an inhibitory receptor that interacts with CD155 and CD112 molecules, is considered as a checkpoint in T and NK cell ac...

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Bibliographic Details
Main Authors: Isabel Valhondo, Fakhri Hassouneh, Nelson Lopez-Sejas, Alejandra Pera, Beatriz Sanchez-Correa, Beatriz Guerrero, Juan M. Bergua, Maria Jose Arcos, Helena Bañas, Ignacio Casas-Avilés, Joaquin Sanchez-Garcia, Josefina Serrano, Carmen Martin, Esther Duran, Corona Alonso, Rafael Solana, Raquel Tarazona
Format: Article
Language:English
Published: MDPI AG 2020-08-01
Series:Cancers
Subjects:
acute myeloid leukemia
DNAM-1
NK cells
NKT-like cells
TACTILE
T cells
Online Access:https://www.mdpi.com/2072-6694/12/8/2171

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https://www.mdpi.com/2072-6694/12/8/2171

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