Methylated CpG dinucleotides in the 5-α reductase 2 gene may explain finasteride resistance in benign prostatic enlargement patients

Methylated CpG dinucleotides in the 5-α reductase 2 gene may explain finasteride resistance in benign prostatic enlargement patients

The inhibition of 5-α reductase type 2 (SRD5A2) by finasteride is commonly used for the management of urinary obstruction resulting from benign prostatic enlargement (BPE). Certain BPE patients showing no SRD5A2 protein expression are resistant to finasteride therapy. Our previous work showed that m...

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Bibliographic Details
Main Authors: Zhe-Min Lin, Dong-Dong Fan, Song Jin, Zhan-Liang Liu, Yi-Nong Niu
Format: Article
Language:English
Published: Wolters Kluwer Medknow Publications 2021-01-01
Series:Asian Journal of Andrology
Subjects:
5-α reductase; benign prostatic enlargement; cpg island; methylated cpg dinucleotides; methylation
Online Access:http://www.ajandrology.com/article.asp?issn=1008-682X;year=2021;volume=23;issue=3;spage=266;epage=272;aulast=Lin

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http://www.ajandrology.com/article.asp?issn=1008-682X;year=2021;volume=23;issue=3;spage=266;epage=272;aulast=Lin

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