Reduced acetylation of TFAM promotes bioenergetic dysfunction in the failing heart

Reduced acetylation of TFAM promotes bioenergetic dysfunction in the failing heart

Summary: General control of amino acid synthesis 5-like 1 (GCN5L1) was previously identified as a key regulator of protein lysine acetylation in mitochondria. Subsequent studies demonstrated that GCN5L1 regulates the acetylation status and activity of mitochondrial fuel substrate metabolism enzymes....

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Bibliographic Details
Main Authors: Manling Zhang, Ning Feng, Zishan Peng, Dharendra Thapa, Michael W. Stoner, Janet R. Manning, Charles F. McTiernan, Xue Yang, Michael J. Jurczak, Danielle Guimaraes, Krithika Rao, Sruti Shiva, Brett A. Kaufman, Michael N. Sack, Iain Scott
Format: Article
Language:English
Published: Elsevier 2023-06-01
Series:iScience
Subjects:
Hematology
Physiology
Molecular biology
Online Access:http://www.sciencedirect.com/science/article/pii/S2589004223010192

Internet

http://www.sciencedirect.com/science/article/pii/S2589004223010192

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