Direct Measurement of B Lymphocyte Gene Expression Biomarkers in Peripheral Blood Transcriptomics Enables Early Prediction of Vaccine Seroconversion

Direct Measurement of B Lymphocyte Gene Expression Biomarkers in Peripheral Blood Transcriptomics Enables Early Prediction of Vaccine Seroconversion

Peripheral blood transcriptome is a highly promising area for biomarker development. However, transcript abundances (TA) in these cell mixture samples are confounded by proportions of the component leukocyte subpopulations. This poses a challenge to clinical applications, as the cell of origin of an...

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Bibliographic Details
Main Authors: Dan Huang, Alex Y. N. Liu, Kwong-Sak Leung, Nelson L. S. Tang
Format: Article
Language:English
Published: MDPI AG 2021-06-01
Series:Genes
Subjects:
vaccination
seroconversion
B lymphocytes
gene expression
transcript abundance
influenza
Online Access:https://www.mdpi.com/2073-4425/12/7/971

Internet

https://www.mdpi.com/2073-4425/12/7/971

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