Chronic morphine alters the presynaptic protein profile: identification of novel molecular targets using proteomics and network analysis.

Chronic morphine alters the presynaptic protein profile: identification of novel molecular targets using proteomics and network analysis.

Opiates produce significant and persistent changes in synaptic transmission; knowledge of the proteins involved in these changes may help to understand the molecular mechanisms underlying opiate dependence. Using an integrated quantitative proteomics and systems biology approach, we explored changes...

Full description

Bibliographic Details
Main Authors: Noura S Abul-Husn, Suresh P Annangudi, Avi Ma'ayan, Dinah L Ramos-Ortolaza, Steven D Stockton, Ivone Gomes, Jonathan V Sweedler, Lakshmi A Devi
Format: Article
Language:English
Published: Public Library of Science (PLoS) 2011-01-01
Series:PLoS ONE
Online Access:http://europepmc.org/articles/PMC3197197?pdf=render

Internet

http://europepmc.org/articles/PMC3197197?pdf=render

Similar Items