Influence of Sodium Bicarbonate on Wall Teichoic Acid Synthesis and β-Lactam Sensitization in NaHCO3-Responsive and Nonresponsive Methicillin-Resistant Staphylococcus aureus

Influence of Sodium Bicarbonate on Wall Teichoic Acid Synthesis and β-Lactam Sensitization in NaHCO3-Responsive and Nonresponsive Methicillin-Resistant Staphylococcus aureus

ABSTRACT Methicillin-resistant Staphylococcus aureus (MRSA) strains pose major treatment challenges due to their innate resistance to most β-lactams under standard in vitro antimicrobial susceptibility testing conditions. A novel phenotype among MRSA, termed “NaHCO3 responsiveness,” where certain st...

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Bibliographic Details
Main Authors: Selvi C. Ersoy, Barbara Gonçalves, Gonçalo Cavaco, Adhar C. Manna, Rita G. Sobral, Cynthia C. Nast, Richard A. Proctor, Henry F. Chambers, Ambrose Cheung, Arnold S. Bayer
Format: Article
Language:English
Published: American Society for Microbiology 2022-12-01
Series:Microbiology Spectrum
Subjects:
methicillin-resistant Staphylococcus aureus (MRSA)
sodium bicarbonate
penicillin-binding proteins (PBPs)
peptidoglycan (PG)
wall teichoic acid (WTA)
β-lactams
Online Access:https://journals.asm.org/doi/10.1128/spectrum.03422-22

Internet

https://journals.asm.org/doi/10.1128/spectrum.03422-22

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