Fine tuning of globin gene expression by DNA methylation.

Fine tuning of globin gene expression by DNA methylation.

Expression patterns in the globin gene cluster are subject to developmental regulation in vivo. While the gamma(A) and gamma(G) genes are expressed in fetal liver, both are silenced in adult erythrocytes. In order to decipher the role of DNA methylation in this process, we generated a YAC transgenic...

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Bibliographic Details
Main Authors: Alon Goren, Giora Simchen, Eitan Fibach, Piroska E Szabo, Keiji Tanimoto, Lyubomira Chakalova, Gerd P Pfeifer, Peter J Fraser, James D Engel, Howard Cedar
Format: Article
Language:English
Published: Public Library of Science (PLoS) 2006-12-01
Series:PLoS ONE
Online Access:http://europepmc.org/articles/PMC1762317?pdf=render

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http://europepmc.org/articles/PMC1762317?pdf=render

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