CNS uptake of bortezomib is enhanced by P-glycoprotein inhibition: implications for spinal muscular atrophy

CNS uptake of bortezomib is enhanced by P-glycoprotein inhibition: implications for spinal muscular atrophy

The development of therapeutics for neurological disorders is constrained by limited access to the central nervous system (CNS). ATP-binding cassette (ABC) transporters, particularly P-glycoprotein (P-gp) and breast cancer resistance protein (BCRP), are expressed on the luminal surface of capillarie...

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Bibliographic Details
Main Authors: Emily Foran, Deborah Y. Kwon, Jonathan H. Nofziger, Eveline S. Arnold, Matthew D. Hall, Kenneth H. Fischbeck, Barrington G. Burnett
Format: Article
Language:English
Published: Elsevier 2016-04-01
Series:Neurobiology of Disease
Subjects:
Spinal muscular atrophy (SMA)
Survival motor neuron (SMN)
P-glycoprotein (P-gp)
Blood brain barrier (BBB)
Bortezomib
Tariquidar
Online Access:http://www.sciencedirect.com/science/article/pii/S0969996116300079

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http://www.sciencedirect.com/science/article/pii/S0969996116300079

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