H+ and Pi Byproducts of Glycosylation Affect Ca2+ Homeostasis and Are Retrieved from the Golgi Complex by Homologs of TMEM165 and XPR1

H+ and Pi Byproducts of Glycosylation Affect Ca2+ Homeostasis and Are Retrieved from the Golgi Complex by Homologs of TMEM165 and XPR1

Glycosylation reactions in the Golgi complex and the endoplasmic reticulum utilize nucleotide sugars as donors and produce inorganic phosphate (Pi) and acid (H+) as byproducts. Here we show that homologs of mammalian XPR1 and TMEM165 (termed Erd1 and Gdt1) recycle luminal Pi and exchange luminal H+...

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Bibliographic Details
Main Authors: Nathan A. Snyder, Christopher P. Stefan, Camille T. Soroudi, Adam Kim, Carlos Evangelista, Kyle W. Cunningham
Format: Article
Language:English
Published: Oxford University Press 2017-12-01
Series:G3: Genes, Genomes, Genetics
Subjects:
Calcium
homeostasis
phosphate
glycosylation
Golgi complex
Online Access:http://g3journal.org/lookup/doi/10.1534/g3.117.300339

Internet

http://g3journal.org/lookup/doi/10.1534/g3.117.300339

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