Sildenafil Recovers Burn-Induced Cardiomyopathy

Sildenafil Recovers Burn-Induced Cardiomyopathy

<b>Background:</b> Severe burn injury initiates a feedback cycle of inflammation, fibrosis, oxidative stress and cardiac mitochondrial damage via the PDE5A-cGMP-PKG pathway. <b>Aim:</b> To test if the PDE5A-cGMP-PKG pathway may contribute to burn-induced heart dysfunction. &l...

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Bibliographic Details
Main Authors: Jake J. Wen, Claire Cummins, Ravi S. Radhakrishnan
Format: Article
Language:English
Published: MDPI AG 2020-06-01
Series:Cells
Subjects:
burn injury
sildenafil
cardiomyopathy
PDE5A
oxidative stress
fibrogenesis
Online Access:https://www.mdpi.com/2073-4409/9/6/1393

Internet

https://www.mdpi.com/2073-4409/9/6/1393

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